学位 博士

  邮箱 xujiezhang@mail.hzau.edu.cn  

  政治面貌：致公党党员

  研究方向 鱼类免疫学与病害防控

教育经历  

2012.09-2015.06 中国科学院水生生物研究所理学博士（专业：遗传学）  

2009.09-2012.06 中国科学院水生生物研究所理学硕士（专业：水生生物学）  

2005.09-2009.06 ylzzcom永利总站线路检测农学学士（专业：水产养殖）    

主要职历  

2018.07-至今 yl6809永利官网，副教授  

2017.08-2018.06 上海海洋大学水产与生命学院，讲师  

2015.09-2017.07 上海海洋大学水产与生命学院，团队博士后

科研成果 

主要研究内容

1. 鱼类B细胞和免疫球蛋白的组成、功能及分化机制

2. 鱼类抗菌多肽的结构、功能、演化及分子设计

3. 鱼用疫苗、免疫佐剂及免疫增强剂的研发

主持和参与的主要科研项目

1. 长江经济带大宗水生生物产业绿色发展教育部工程研究中心项目（2662021SSSY004），2021/01/01-2023/12/31，20万元，主持

2. 国家自然科学基金面上项目（31972824），2020/01-2023/12，58万元，主持

3. 国家重点研发计划蓝色粮仓科技创新专项课题（2018YFD0900503），2018/12-2022/12，45.4万元，子任务主持人

4. 中央高校基本科研业务费专项基金-科研启动经费（2662018QD053），2018/09-2021/09，20万元，主持

5. 国家自然科学基金青年科学基金项目（31602184），2017/01-2019/12，20万元，主持

6. 国家自然科学基金面上项目（31472307），2015/01-2018/12，88万元，参与

7. 国家自然科学基金青年科学基金项目（31101623），2012/01-2014/12，23万元，参与

8. 国家自然科学基金面上项目（31070112），2011/01-2013/12，32万元，参与

9. 企业横向课题（707122105），2022/01/01-2022/12/31，20万元，主持

代表性学术论文

1. Jie Wang, Chang-Song Wu, Ya-Zhen Hu, Lan Yang, Xu-Jie Zhang*, Yong-An Zhang*. Plasmablasts induced by chitosan oligosaccharide secrete natural IgM to enhance the humoral immunity in grass carp. Carbohydrate Polymers, 2022, 281: 119073.

2. Ya-Zhen Hu, Zi-You Ma, Chang-Song Wu, Jie Wang, Yong-An Zhang*, Xu-Jie Zhang*. LECT2 is a novel antibacterial protein in vertebrates. Journal of Immunology, 2022, 208(8): 2100812.

3. Zi-You Ma, Jia-Xin Liang, Wen-Shuo Li, Yuan Sun, Chang-Song Wu, Ya-Zhen Hu, Jun Li, Yong-An Zhang*, Xu-Jie Zhang*. Complement C3a Enhances the Phagocytic Activity of B Cells Through C3aR in a Fish. Frontiers in Immunology, 2022, 13: 873982.

4. Chang‑Song Wu, Zi‑You Ma, Guo‑Dong Zheng, Shu‑Ming Zou, Xu‑Jie Zhang*, Yong‑An Zhang*. Chromosome-level genome assembly of grass carp (Ctenopharyngodon idella) provides insights into its genome evolution. BMC Genomics, 2022, 23: 271.

5.  Zheng-Wei Cui, Xiang-Yang Zhang, Chang-Song Wu, Yong-An Zhang, Yang Zhou*, Xu-Jie Zhang*. Membrane IgM⁺ plasma cells in grass carp (Ctenopharyngodon idella): Insights into the conserved evolution of IgM⁺ plasma cells in vertebrates. Developmental and Comparative Immunology, 2020, 106: 103613.

6.  Zheng-Wei Cui, Xiang-Yang Zhang, Xiao-Hua Chen*, Xu-Jie Zhang*, Yong-An Zhang. Splicing variants of grass carp (Ctenopharyngodon idellus) IL-21: Functions in IgM⁺ B cell proliferation and IgM secretion. Developmental and Comparative Immunology, 2020, 110:  103728.

7. Xu-Jie Zhang^#, Xiang-Yang Zhang^#, Peng Wang, Yong-An Zhang*. Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates. Developmental and Comparative Immunology, 2018, 89: 73-82.

8. Xu-Jie Zhang, Peng Wang, Nu Zhang, Dan-Dan Chen, Pin Nie, Jia-Le Li*, Yong-An Zhang*. B Cell Functions Can Be Modulated by Antimicrobial Peptides in Rainbow Trout Oncorhynchus mykiss: Novel Insights into the Innate Nature of B cells in Fish, Frontiers in Immunology, 2017, 8: 388.

9. Nu Zhang, Xu-Jie Zhang, Dan-Dan Chen, J. Oriol Sunyer, Yong-An Zhang*. Molecular characterization and expression analysis of three subclasses of IgT in rainbow trout (Oncorhynchus mykiss). Developmental and Comparative Immunology, 2017, 70: 94-105.

10. Long-Feng Lu, Shun Li, Xiao-Bing Lu, Scott E LaPatra, Nu Zhang, Xu-Jie Zhang, Dan-Dan Chen, Pin Nie, Yong-An Zhang*. Spring Viremia of Carp Virus N Protein Suppresses Fish IFN1 Production by Targeting the Mitochondrial Antiviral Signaling Protein. Journal of Immunology, 2016, 196: 3744-3753.

11. Nu Zhang, Xu-Jie Zhang, Yu-Long Song, Xiao-Bing Lu, Dan-Dan Chen, Xiao-Qin Xia, J. Oriol Sunyer, Yong-An Zhang*. Preferential combination between the light and heavy chain isotypes of fish immunoglobulins. Developmental and Comparative Immunology, 2016, 61:169-179.

12. Xia Guo, Dan-Dan Chen, Kai-Song Peng, Zheng-Wei Cui, Xu-Jie Zhang, Shun Li, Yong-An Zhang*. Identification and characterization of Bacillus subtilis from grass carp (Ctenopharynodon idellus) for use as probiotic additives in aquatic feed. Fish Shellfish Immunology, 2016, 52: 74-84.

13. Xu-Jie Zhang, Xiang-Yang Zhang, Nu Zhang, Xia Guo, Kai-Song Peng, Han Wu, Long-Feng Lu, Nan Wu, Dan-Dan Chen, Shun Li, Pin Nie, Yong-An Zhang*. Distinctive Structural Hallmarks and Biological Activities of the Multiple Cathelicidin Antimicrobial Peptides in a Primitive Teleost Fish. Journal of Immunology, 2015, 194(10): 4974-4987.

14. Xu-Jie Zhang, Wu-Ming Yang, Han Wu, Xiao-Ning Gong, Ai-Hua Li*. Multilocus sequence typing revealed a clonal lineage of Aeromonas hydrophila caused motile Aeromonas septicemia outbreaks in pond-cultured cyprinid fish in an epidemic area in central China. Aquaculture, 2014, 432: 1-6.

15. Xu-Jie Zhang, Wu-Ming Yang, De-Feng Zhang, Tong-Tong Li, Xiao-Ning Gong, Ai-Hua Li*. Does the gastrointestinal tract serve as the infectious route of Aeromonas hydrophila in crucian carp (Carassius carassius)? Aquaculture Research, 2013, 46(1): 141-154.